vivoPHIX™, genoPHIX™ and virusPHIX™
Our flagship stabilization solutions — vivoPHIX™, genoPHIX™, virusPHIX™ and virusPHIX-P9™ — are designed for a wide range of applications within the life sciences. vivoPHIX™ leverages advanced molecular stabilization technology to ensure sample integrity during tissue fixation, dissociation, and single-cell workflows, including scRNA-seq and CITE-seq. virusPHIX™
facilitates virus inactivation and secure transport, preserving molecular fidelity for improved diagnostic accuracy and high-quality data generation.
For mRNA-LNP vaccine and therapeutic thermostabilization, please click here to learn more about TheraPHIX™.
Fixation Before Dissociation Using a Deep Eutectic Solvent Preserves In Vivo States and Phospho-Signaling in Single-Cell Sequencing
Single-cell RNA sequencing presents an opportunity to deconstruct cellular networks but is limited by the loss of biological information. In this study, a new method of fixation before dissociation using a deep eutectic solvent (DES) is presented.
This method enables multiple domains of in vivo biological data, including morphology, RNA, proteins and posttranslational modifications to be preserved.
The study demonstrates how deep eutectic based fixatives will allow the accurate reconstruction of in vivo cellular networks and uncover links between intracellular pathways.
Core features of our technology
vivoPHIX™, genoPHIX™ and virusPHIX™ are patented, universal clinical sample stabilization and inactivation reagents with variously proven Research Use Only (RUO) and diagnostics applications including cell and tissue fixation, ISH, IF, tissue dissociation, scRNA-seq, NGS, viral transport, RT-PCR and Lateral Flow rapid tests
Cell and Tissue Fixation
Cellular morphology of fresh & fresh frozen tissue is conserved
Samples can be embedded in paraffin for staining
Compatible with GFP detection, IF, IHC, ISH H&E and RNAscope imaging
RNA, Protein and DNA Stablization
Long-term biomolecule stabilisation
Substantially improves RNA and DNA quality compared to competing products
Compatible with front-end RNA purification kits even when the sample is blood
Tissue Dissociation
Easy non-protease dissociation into individual cells retaining original 3D morphological characteristics with scRNAseq compatibility
Ready-to-use protocol for single-cell RNA-seq
Can be used for 16S NGS and WTA metagenomics
Virus Inactivation, Bacteria /Fungi/Parasite Killing Tests
Inactivates viruses, bacteria & yeast
Easy storage & transportation of sensitive samples
Stabilises HCV RNA for at least 12 months and SARS-CoV-2 RNA for least 6 weeks at 20°C
Safe Handling
Very low toxicity, non-flammable, non-crosslinking
No hood : carcinogen-free & low volatility reagent unlike formaldehyde
Partially biodegradable
Room temperature use
virusPHIX™ Virus Transport Media, SARS-CoV-2 inactivation, RNA and Antigen Stabilisation
Improves biosafety and logistics when transporting Covid-19 samples
Protects samples from excessive heat damage
Works with both swabs and saliva for Nucleic Acid and Antigen testing
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vivoPHIX™, genoPHIX™, virusPHIX™ and virusPHIX-P9™ are patented next generation cell and tissue fixatives, biomolecule stabilisers with powerful virus and bacterial inactivation properties.
Our reagents are universally compatible with all sample types including viruses, bacteria, fungi, parasites, plants and animal cells and tissues. Both liquid and solid samples are rapidly and completely rendered fixed, stabilised and inactivated.
RNAssist technology supports a wide range of life science applications, including tissue fixation and dissociation, single-cell multiomics (scRNA-seq, CITE-seq), and virus inactivation and transport for enhanced diagnostic testing.
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